林丽清

浏览次数:241

姓名:

林丽清

所在单位:

药学院药物分析学系

性别:

主要研究方向:

纳米生物传感器

职称:

教授

办公电话:

0591-22862016

学历:

博士学位  

电子邮箱:

Fjmu_lin@126.com

硕博导:

硕导


个人简介:林丽清,女,医学博士,教授,硕士生导师,1997年毕业于福建医科大学预防医学专业,获医学学士学位,2008年、2012年先后获医学硕士、医学博士学位,2014-2015年公派美国University of Illinois研修。近年来主要从事纳米生物传感器研制及用于临床肿瘤标志物检测等领域的科研与教学工作。先后主持福建省自然科学基金2项、福建省卫生系统中青年骨干人才培养项目、福建省教育厅基金、福建省卫生厅青年基金及校级教授学术发展基金各1项;作为主要研究成员参与国家自然科学基金1项,863专题项目1项。近年来研究成果陆续在《Biosensors and Bioelectronics》、《International Journal of Nanomedicine》、《Sensors and Actuators B: Chemical》等刊物上发表论文30余篇,论文SCI引用次数300多次。获国家专利1项。

教学工作面向本科生主讲《药物分析》、《分析化学》与《卫生化学》,面向研究生主讲《现代药物分析》课程。为基础/检验五年制专业和检验/实验技术专业《分析化学》课程负责人。

科研成果:主持承担省市各级各类科研课题5项,重点在纳米粒子和酶信号放大传感器研究新型生物传感器对相关白血病基因超敏感检测胰腺癌点突变基因特异性检测等领域进行深入的专门研究。

发表论文

(1) Yiwei Shen, Zhouliang Sun, Peiying Shi, Gang Wang, Youjia Wu, Shaoguang Li, Yanjie Zheng, Liying Huang, Liqing Lin, Xinhua Lin, Hong Yao. Anticancer effect of petroleum ether extract from Bidens pilosa L and its constituent's analysis by GC-MS. Journal of Ethnopharmacology. 2018, 217, 126-133. (通讯作者)

(2) Zhengjun Huang, Zhouqian Jiang, Chengfei Zhao, Wendi Han, Liqing Lin, Ailin Liu, Shaohuang Weng ,  Xinhua Lin. Simple and effective label-free electrochemical immunoassay for carbohydrate antigen 19-9 based on polythionine-Au composites as enhanced sensing signals for detecting different clinical samples. Int. J. Nanomedicine. 2017, 12, 3049-3058. (通讯作者)

(3) Chengfei Zhao, Sufang Yang, Liqing Lin, Shaohuang Weng, Qicai Liu, Ailin Liu, Xinhua Lin. Chronocoulometric biosensor forK-ras point mutation detection based onE. Coli DNAligase and AuNPs amplification effects. Sens. Actuators B. 2016, 223, 46-951. (通讯作者)

(4) Chengfei  Zhao, Feng Gao, Shaohuang Weng, Qicai Liu, Liqing Lin, Xinhua Lin. An electrochemical sensor based on DNA polymerase and HRP-SiO2 nanoparticles for the ultrasensitive detection of K-ras gene point mutation. (通讯作者)

(5) Zongen Liu,  Xiaohui Cai,  Xuefang Lin,  Yanjie Zheng,  Yangting Wu,  Pingping Chen,  Shaohuang Weng,  Liqing Lin , Xinhua Lin. Signal-on fluorescent sensor based on GQDs–MnO2composite for glutathione. Anal. Methods. 2016, 8, 2366-2374. (通讯作者)

(6) Shaohuang Weng, Qicai Liu, Chengfei Zhao, Guolin Hong, Zhouqian Jiang, Liqing Lin, Yuanzhong Chen, Xinhua Lin.Sensitive electrochemical immunoassay based on polythionine-Au nanocomposites asenhanced sensing signal for selective detection of biomarker with high isoelectricpoint. Sens. Actuators B. 2015, 216, 307-315. (通讯作者)

(7) Zhouqian Jiang, Chengfei Zhao, Liqing Lin, Shaohuang Weng, Qicai Liu, Xinhua Lin. A label-free electrochemicalimmunosensor based on poly(thionine)–SDS nanocomposites for CA19-9 detection. Anal. Methods. 2015, 7, 4508-4513. (通讯作者)

(8) Liqing Lin, Ailin Liu, Chengfei Zhao, Shaohuang Weng, Yun Lei, Qicai Liu, Xinhua Lin,  Yuanzhong Chen. A chronocoulometric sensor for amplified detection of K-ras mutationbased on site-specific DNA cleavage of restriction endonuclease. Biosen. Bioelectron. 2013, 42 (15), 409-414. (IF: 5.602)

(9) Liqing Lin, Shaohuang Weng, Chengfei Zhao, Qicai Liu, Ailin liu, Xinhua Lin. Hairpin biosensor with enzyme tagged AuNPs as tracer foramperometric detection of K-ras mutation gene. Electrochimica Acta. 2013, 108, 808-813. (IF: 3.642)

(10) Liqing Lin, Qicai Liu, Liman Wang, Ailin Liu, Shaohuang Weng, Yun Lei, Wei Chen, Xinhua Lin, Yuanzhong Chen. Enzyme-amplifiedelectrochemical biosensor for detection of PML-RARα fusion gene based on hairpin probe. Biosen. Bioelectron. 2011, 28 (1), 277- 283. (IF: 5.361)

(11) Liqing Lin,  Jie Kang, Shaohuang Weng, Jinghua Chen, Ailin Liu,  Xinhua Lin, Yuanzhong Chen. Lockednucleic acids biosensor for detection of BCR/ABL fusion gene using Benzoate BinuclearCopper(Ⅱ) Complex as hybridization indicator. Sens. Actuators B. 2011, 155 (1), 1-7. (IF: 3.368)

(12)  liqing Lin,  Jing Chen, Qihuang Lin, Wei Chen, Jinghua Chen, Hong Yao, Ailin Liu, Xinhua Lin, Yuanzhong Chen. Electrochemical biosensor based on nanogold-modified poly-eriochromeblack T film for BCR/ABL fusion gene assay by using hairpin probe. Talanta. 2010, 5(15), 2113-2119. (IF: 3.722)

奖励情况2014年获福建省第十一届自然科学优秀学术论文三等奖和福建省卫生系统中青年骨干人才称号(排名第一),2016年获福建省科技进步奖一等奖(排名第五)